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In addition to these symptoms, a major complaint of patients suffering from IC is pelvic pain, which originates from the urethra, vagina or rectum, amongst other viscera [3]

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TED: TET DNA demethylases Glutamine can be synthetized by the cells through GLUL/glutamine synthetase (GS) which catalyses the condensation reaction between glutamate and ammonia in an ATP-dependent manner and generates glutamine

Moreover, GO analysis of the cellular component also showed that mitochondrion, mitochondrial inner membrane, mitochondrial matrix, and mitochondrial respiratory complex I were enriched in the top 20 cellular components, which suggested the regulation of cellular homeostasis (Supplementary Fig